pI: 6.5028 |
Length (AA): 619 |
MW (Da): 69790 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_130316)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_00265 | hypothetical protein |
Candida albicans | CaO19_6476 | hypothetical protein |
Candida albicans | CaO19.13830 | similar to S. cerevisiae YLR114C |
Candida albicans | CaO19.6476 | similar to S. cerevisiae YLR114C |
Caenorhabditis elegans | CELE_T26A5.6 | Protein T26A5.6 |
Dictyostelium discoideum | DDB_G0285201 | hypothetical protein |
Drosophila melanogaster | Dmel_CG11178 | CG11178 gene product from transcript CG11178-RC |
Echinococcus granulosus | EgrG_000712300 | late secretory pathway protein avl9 |
Echinococcus multilocularis | EmuJ_000712300 | late secretory pathway protein avl9 |
Homo sapiens | ENSG00000105778 | AVL9 homolog (S. cerevisiase) |
Loa Loa (eye worm) | LOAG_02340 | hypothetical protein |
Mus musculus | ENSMUSG00000029787 | AVL9 homolog (S. cerevisiase) |
Onchocerca volvulus | OVOC9488 | Late secretory pathway protein AVL9 homolog |
Saccharomyces cerevisiae | YLR114C | Avl9p |
Schistosoma japonicum | Sjp_0118360 | Protein KIAA0241, putative |
Schistosoma japonicum | Sjp_0310200 | Protein KIAA0241 homolog, putative |
Schistosoma mansoni | Smp_152140 | hypothetical protein |
Schmidtea mediterranea | mk4.004944.00 | |
Trichomonas vaginalis | TVAG_061320 | conserved hypothetical protein |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.